Cladospolide B, an Antifungal Polyketide Isolated from the Fungus, Lambertella brunneola

Authors

  • Wilanfranco C. Tayone Asst. Professor, Mathematics and Natural Sciences Department, Davao Oriental State College of Science & Technology
  • Noboru Takada Asso. Professor, Faculty of Agriculture and Life Science, Hirosaki University

DOI:

https://doi.org/10.59120/drj.v8i1.34

Keywords:

cladospolide B antifungal, chromatography, Nuclear Magnetic Resonance (NMR), structure elucidation

Abstract

A polyketide known as cladospolide B, (Z)-4,5-dihydroxy-2-dodecen-11-olide was isolated from the culture broth of the fungus, Lambertella brunneola. The structure elucidation of this compound was based on Nuclear Magnetic Resonance (NMR) spectroscopic data and Mass Spectroscopy (MS) analyses. Cladospolide B exhibited a seemingly weak antifungal activity and inhibited the hyphalgrowth of the phyto-pathogenicfungus, Helminthosporium oryzae(=Cochliobolus miyabeanus) by 50 % at more than 1 mg/mL but less than 5 mg/mL (1 < IC50 <5). This is the first report on the isolation of cladospolide B from L. brunneola.

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References

Fu H. (1994). Engineered biosynthesis of novel polyketides: Stereochemical course of two reactions catalyzed by a polyketide synthase. Biochemistry. 33 (31): 9321-9326.

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Published

2012-12-04

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Section

Articles

How to Cite

Tayone, W., & Takada, N. (2012). Cladospolide B, an Antifungal Polyketide Isolated from the Fungus, Lambertella brunneola. Davao Research Journal, 8(1), 10-14. https://doi.org/10.59120/drj.v8i1.34